MindPharm Blog

This interesting study describes a new class of broad-spectrum antivirals effective against
enveloped viruses that target the viral lipid membrane and compromises its ability to mediate virus?cell fusion. 

A broad-spectrum antiviral targeting entry of enveloped viruses ? PNAS

an antiviral small molecule, LJ001, effective against numerous enveloped viruses including Influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1. In sharp contrast, the compound had no effect on the infection of nonenveloped viruses. In vitro and in vivo assays showed no overt toxicity.