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Saturday, October 24, 2009

Generically engineered to over-express the NR2B gene, Hobbie-J consistently out-performed the normal Long Evans rat at complex tasks.  A similarly engineered mouse, Doogie, showed memory improvement a decade earlier.

Smart rat 'Hobbie-J' produced by over-expressing a gene that helps brain cells communicate
Dubbed Hobbie-J after a smart rat that stars in a Chinese cartoon
book, the transgenic rat was able to remember novel objects, such as a toy she played with, three times longer than the average Long Evans female rat, which is considered the smartest rat strain. Hobbie-J was much better at more complex tasks as well, such as remembering which path she last traveled to find a chocolate treat.


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