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Scientists have developed a new version of a medication, first isolated from the saliva of sea snails, that could be taken in pill form to relieve the most severe forms of pain as effectively as morphine but without risking addiction. An article on the topic appears in the current issue of Chemical & Engineering News
Accentia Biopharmaceuticals and Biovest International have developed a non-Hodgkin?s lymphoma (NHL) vaccine that teaches the body?s immune system to identify and destroy tumor cells while leaving healthy tissue intact. The vaccine, called BiovaxID, is already in Phase III clinical trials.
A study has found that researchers can detect Alzheimer's disease with a brain scan using radioactive dye called AV-45 or florbetapir, which was developed by Philadelphia-based Avid Radiopharmaceuticals.
Researchers at the Fred Hutchinson Cancer Research Center in Seattle, Wash., led by Emily White, Ph.D., a member of the public health sciences division, asked 35,016 postmenopausal women who did not have a history of breast cancer to complete a 24-page questionnaire about their use of non-vitamin, non-mineral ?specialty? supplements in the Vitamins and Lifestyle (VITAL) cohort study.
After six years of follow-up, 880 cases of breast cancer were identified using the Surveillance, Epidemiology and End Results registry.
Regular use of fish oil supplements, which contain high levels of the omega-3 fatty acids, EPA and DHA, was linked with a 32 percent reduced risk of breast cancer. The reduction in risk appeared to be restricted to invasive ductal breast cancer, the most common type of the disease.
"Now, for the first time, we can produce large quantities of human embryonic stem cells in an environment that is completelychemically defined," says professor Karl Tryggvason, who led the study. "This opens up new opportunities for developing different types of cell which can then be tested for the treatment of disease."
Together with researchers at the Harvard Stem Cell Institute, the researchers have also shown that in the same way they can culture what are known as reprogrammed stem cells, which have been converted "back" from tissue cells to stem cells.
Mice implanted with cancer cells and treated with the small molecule macroketone lived a full life without any cancer spread, compared with control animals, which all died of metastasis. When macroketone was given a week after cancer cells were introduced, it still blocked greater than 80 percent of cancer metastasis in mice.
This individual will be responsible for managing a lab-based team and external collaborators developing new products for the ESC and iPS research market. This includes culture systems for both undifferentiated and differentiated cells, media development and cell-based assays. Candidates should have a Ph.D. in the Life Sciences or related discipline, with 3-5 years of relevant commercial experience, or MS/BS with 10+ years experience in the field. Expertise in human pluripotent cell culture is required; experience with adult stem cells and other primary cells is desirable. Additional requirements include strong supervisory and leadership skills, proven track record of developing and launching cell-based products, project management skills and communication skills.
For consideration please contact;
Stephanie Miller
MindPharm, LLC
410-448-4522
stephanie.miller@mindpharm.net
Posted by Stephanie at 01:11 PM. Filed under: Current Opportunities
This individual will be responsible for managing a lab-based team developing and transferring processes for GMP manufacturing of cell-based therapeutics for external clients. This includes scale-up with closed systems, optimizing key culture parameters, identifying and testing appropriate raw materials, disposables and equipment, and developing and optimizing cell harvest and formulation. Candidates should have a Ph.D. in the Life Sciences or related discipline, with 3-5 years of relevant commercial experience, or MS/BS with 10+ years experience in the field. Expertise in large-scale culture of stem cells is required; experience with GMP manufacturing, downstream processing and cell-based assays is desirable. Additional requirements include strong supervisory and leadership skills, project management skills and communication skills.
For consideration please contact;
Stephanie Miller
MindPharm, LLC
410-448-4522
stephanie.miller@mindpharm.net
Posted by Stephanie at 01:08 PM. Filed under: Current Opportunities
This individual will be responsible for managing a lab-based team developing and transferring processes for GMP manufacturing of cell-based therapeutics for external clients. This includes scale-up with closed systems, optimizing key culture parameters, identifying and testing appropriate raw materials, disposables and equipment, and developing and optimizing cell harvest and formulation. Candidates should have a Ph.D. in the Life Sciences or related discipline, with 3-5 years of relevant commercial experience, or MS/BS with 10+ years experience in the field. Expertise in large-scale culture of stem cells is required; experience with GMP manufacturing, downstream processing and cell-based assays is desirable. Additional requirements include strong supervisory and leadership skills, project management skills and communication skills.
For consideration please contact;
Stephanie Miller
MindPharm, LLC
410-448-4522
stephanie.miller@mindpharm.net
Posted by Stephanie at 01:05 PM. Filed under: Current Opportunities
These results, published in the March 21 advance online edition of the journal Nature, demonstrate the feasibility of using both nanoparticles and RNAi-based therapeutics in patients, and open the door for future "game-changing" therapeutics that attack cancer and other diseases at the genetic level, says Mark Davis, the Warren and Katharine Schlinger Professor of Chemical Engineering at Caltech, and the research team?s leader.
Humans could regrow body parts like some amphibians - TelegraphAccording to the Wistar researchers, the loss of p21 causes the cells of these mice to behave more like regenerating embryonic stem cells rather than adult mammalian cells. This means they act as if they (are) creating rather than mending the body.
Their findings, published in the Proceedings of the National Academy of Sciences, provide solid evidence to link tissue regeneration to the control of cell division.
British researchers have devised a way to capture vaccines in a glass-like membrane composed of sugar, a feat that could eliminate the need for refrigeration of vaccines and revolutionize their distribution in the developing world. Tests have shown that the technique can preserve vaccines for as long as a year at tropical temperatures, according to the report Wednesday in the journal Science Translational Medicine.
an antiviral small molecule, LJ001, effective against numerous enveloped viruses including Influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1. In sharp contrast, the compound had no effect on the infection of nonenveloped viruses. In vitro and in vivo assays showed no overt toxicity.
Spray-on liquid glass is transparent, non-toxic, and can protect virtually any surface against almost any damage from hazards such as water, UV radiation, dirt, heat, and bacterial infections. The coating is also flexible and breathable, which makes it suitable for use on an enormous array of products.
Dubbed Hobbie-J after a smart rat that stars in a Chinese cartoonbook, the transgenic rat was able to remember novel objects, such as a toy she played with, three times longer than the average Long Evans female rat, which is considered the smartest rat strain. Hobbie-J was much better at more complex tasks as well, such as remembering which path she last traveled to find a chocolate treat.
